It has been demonstrated that bacteria can be trained to become antibiotic-resistant by simulating evolutionary pressures in a controlled environment via the employment of Microbial Evolution and Growth Arena (MEGA) plates (Baym, M., et al., 2016). It is also known that bacteriophages (a class of viruses) can act as ‘natural predators’ for certain strains of bacteria.
Therefore, the question can be raised as to whether MEGA-plate-like techniques can be employed to train bacteriophages against antibiotic-resistant bacteria by simulating evolutionary pressures between the two groups in a controlled environment, in favour of the bacteriophage candidates.
References
Baym M. et al (2016) Spatiotemporal microbial evolution on antibiotic landscapes. Science, 353(6304), pp.1147–1151. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC5534434/ (Accessed: 12 April 2026).
Curtis Holt - Studio / Lab 